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• SIGMA A System for integrated Genome Map Assembly SIGMA is a graphical database tool designed for building and viewing integrated genome maps. A number of human and yeast chromosomes are currently available for viewing.
• Drosophila Genome Project Increasing biological content and resolution of the ph During the last few years the Drosophila community has begun to realize that it needs an integrated genome program. While the polytene chromosomes have provided a 50-100 kb scale cytogenetic map of the euchromatin for more that 50 years, a true physical map and ultimately the complete genome sequence will be required as workers increasingly exploit Drosophila to understand gene function. The Drosophila Genome Center described in this proposal would establish an integrated program that will focus initially on building a physical map with about 20 kb resolution. Such a map would permit any investigator to identify genomic regions of interest that are represented in any convenient cloning vector. Perhaps of greatest significance, the strategy will use known genes and lethal P element insertions to integrate the physical and genetic maps.