4. Nucleotide Metabolism
4.1 Purine metabolism [MAP:00230]
b0049 apaH; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) (diadenosine
tetraphosphatase). [EC:3.6.1.41] [SP:APAH_ECOLI]
*b0060 polB, dina; DNA polymerase II (pol II). [EC:2.7.7.7] [SP:DPO2_ECOLI]
b0104 guaC; GMP reductase (guanosine 5'-monophosphate oxidoreductase).
[EC:1.6.6.8] [SP:GUAC_ECOLI]
b0125 hpt; hypoxanthine phosphoribosyltransferase (HPRT). [EC:2.4.2.8]
[SP:HPRT_ECOLI]
b0160 dgt; deoxyguanosinetriphosphate triphosphohydrolase (DGTPase).
[EC:3.1.5.1] [SP:DGTP_ECOLI]
*b0184 dnaE, polc; DNA polymerase III, alpha chain. [EC:2.7.7.7] [SP:DP3A_ECOLI]
*b0215 dnaQ, mutd; DNA polymerase III, epsilon chain. [EC:2.7.7.7]
[SP:DP3E_ECOLI]
b0238 GPT, gpp, gxu; xanthine-guanine phosphoribosyltransferase (XGPRT).
[EC:2.4.2.22] [SP:XGPT_ECOLI]
b0469 apt; adenine phosphoribosyltransferase (APRT). [EC:2.4.2.7] [SP:APT_ECOLI]
*b0470 dnaX, dnaz; DNA polymerase III subunits gamma and tau. [EC:2.7.7.7]
[SP:DP3X_ECOLI]
b0474 adk, plsA, dnaw; adenylate kinase (ATP-AMP transphosphorylase).
[EC:2.7.4.3] [SP:KAD_ECOLI]
b0477 gsk; inosine-guanosine kinase. [EC:2.7.1.73] [SP:INGK_ECOLI]
*b0480 ushA; UDP-sugar hydrolase precursor (UDP-sugar diphosphatase) (UDP-
sugar pyrophosphatase) (5'-nucleotidase ). [EC:3.1.3.5 3.6.1.45]
[SP:USHA_ECOLI]
b0512 ybbX; putative allantoinase. [EC:3.5.2.5] [SP:ALLA_ECOLI]
b0522 purK; phosphoribosylaminoimidazole carboxylase ATPase subunit (air
carboxylase) (AIRC). [EC:4.1.1.21] [SP:PURK_ECOLI]
b0523 purE; phosphoribosylaminoimidazole carboxylase catalytic subunit (air
carboxylase) (AIRC). [EC:4.1.1.21] [SP:PUR6_ECOLI]
*b0640 holA; DNA polymerase III, delta subunit. [EC:2.7.7.7] [SP:HOLA_ECOLI]
*b1099 holB; DNA polymerase III, delta' subunit. [EC:2.7.7.7] [SP:HOLB_ECOLI]
*b1131 purB; adenylosuccinate lyase (adenylosuccinase) (ASL). [EC:4.3.2.2]
[SP:PUR8_ECOLI]
*b1207 prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
b1623 add; adenosine deaminase (adenosine aminohydrolase). [EC:3.5.4.4]
[SP:ADD_ECOLI]
*b1838 prpA; serine/threonine protein phosphatase prpa. [EC:3.1.3.16]
[SP:PRPA_ECOLI]
*b1842 holE; DNA polymerase III, theta subunit. [EC:2.7.7.7] [SP:HOLE_ECOLI]
b1982 amn; AMP nucleosidase. [EC:3.2.2.4] [SP:AMN_ECOLI]
*b2234 nrdA, dnaf; ribonucleoside-diphosphate reductase 1 alpha chain
(ribonucleotide reductase 1) (b1 protein) (r1 protein). [EC:1.17.4.1]
[SP:RIR1_ECOLI]
*b2235 nrdB, ftsb; ribonucleoside-diphosphate reductase 1 beta chain
(ribonucleotide reductase 1) (b2 protein) (r2 protein). [EC:1.17.4.1]
[SP:RIR2_ECOLI]
*b2311 ubiX, dedf; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (polyprenyl P-
hydroxybenzoate decarboxylase). [EC:4.1.1.-] [SP:UBIX_ECOLI]
*b2312 purF; amidophosphoribosyltransferase (glutamine
phosphoribosylpyrophosphate amidotransferase) (ATASE). [EC:2.4.2.14]
[SP:PUR1_ECOLI]
b2476 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR
synthetase). [EC:6.3.2.6] [SP:PUR7_ECOLI]
b2499 purM, purg; phosphoribosylformylglycinamidine cyclo-ligase (AIRS)
(phosphoribosyl-aminoimidazole synthetase) (air synthase). [EC:6.3.3.1]
[SP:PUR5_ECOLI]
*b2500 purN; phosphoribosylglycinamide formyltransferase (GART) (GAR
transformylase) (5'-phosphoribosylglycinamide transformylase).
[EC:2.1.2.2] [SP:PUR3_ECOLI]
b2502 ppx; exopolyphosphatase (metaphosphatase). [EC:3.6.1.11] [SP:PPX_ECOLI]
*b2507 guaA; GMP synthase (glutamine-hydrolyzing) (glutamine amidotransferase)
(GMP synthetase). [EC:6.3.5.2] [SP:GUAA_ECOLI]
b2508 guaB; inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase)
(IMPDH) (IMPD). [EC:1.1.1.205] [SP:IMDH_ECOLI]
*b2518 ndk; nucleoside diphosphate kinase (NDK) (ndp kinase). [EC:2.7.4.6]
[SP:NDK_ECOLI]
b2557 purL, puri; phosphoribosylformylglycinamidine synthase (fgam synthase)
(formylglycineamide ribotide amidotransferase) (fgarat). [EC:6.3.5.3]
[SP:PURL_ECOLI]
*b2675 nrdE; ribonucleoside-diphosphate reductase 2 alpha chain
(ribonucleotide reductase 2) (r1e protein). [EC:1.17.4.1] [SP:RIR3_ECOLI]
*b2676 nrdF; ribonucleoside-diphosphate reductase 2 beta chain (ribonucleotide
reductase 2) (r2f protein). [EC:1.17.4.1] [SP:RIR4_ECOLI]
*b2750 cysC; adenylylsulfate kinase (APS kinase) (ATP adenosine-5'-
phosphosulfate 3'-phosphotransferase). [EC:2.7.1.25] [SP:CYSC_ECOLI]
*b2751 cysN; sulfate adenylate transferase subunit 1 (ATP-sulfurylase).
[EC:2.7.7.4] [SP:CYSN_ECOLI]
*b2752 cysD; sulfate adenylate transferase subunit 2 (ATP-sulfurylase).
[EC:2.7.7.4] [SP:CYSD_ECOLI]
b2784 relA; GTP pyrophosphokinase (ATP:GTP 3'-pyrophosphotransferase) (ppgpp
synthetase I). [EC:2.7.6.5] [SP:RELA_ECOLI]
*b3164 pnp; polynucleotide phosphorylase [EC:2.7.7.8]
*b3295 rpoA, pez, phs, sez; DNA-directed RNA polymerase alpha chain
(transcriptase alpha chain) (RNA polymerase alpha subunit). [EC:2.7.7.6]
[SP:RPOA_ECOLI]
*b3461 rpoH, htpr, hin, fam; RNA polymerase sigma-32 factor (heat shock
regulatory protein f33.4). [EC:2.7.7.6] [SP:RP32_ECOLI]
b3648 gmk, spoR; guanylate kinase (GMP kinase). [EC:2.7.4.8] [SP:KGUA_ECOLI]
*b3649 rpoZ; DNA-directed RNA polymerase omega chain (transcriptase omega
chain) (RNA polymerase omega subunit). [EC:2.7.7.6] [SP:RPOZ_ECOLI]
b3650 spoT; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
((PPGPP)ase) (penta-phosphate guanosine-3'-pyrophosphohydrolase).
[EC:3.1.7.2] [SP:SPOT_ECOLI]
b3665 yicP; probable adenine deaminase (ADENase) (adenine aminase).
[EC:3.5.4.2] [SP:ADEC_ECOLI]
*b3701 dnaN; DNA polymerase III, beta chain. [EC:2.7.7.7] [SP:DP3B_ECOLI]
b3779 gppA; guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
(guanosine pentaphosphate phosphohydrolase) (pppgpp-5'-
phosphohydrolase). [EC:3.6.1.40] [SP:GPPA_ECOLI]
b3806 cyaA, cya; adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl
cyclase). [EC:4.6.1.1] [SP:CYAA_ECOLI]
*b3863 polA, resa; DNA polymerase I (POL I). [EC:2.7.7.7] [SP:DPO1_ECOLI]
*b3987 rpoB, gron, nitb, rif, ron, stl, stv, tabd; DNA-directed RNA polymerase
beta chain (transcriptase beta chain) (RNA polymerase beta subunit).
[EC:2.7.7.6] [SP:RPOB_ECOLI]
*b3988 rpoC, tabb; DNA-directed RNA polymerase beta' chain (transcriptase
beta' chain) (RNA polymerase beta' subunit). [EC:2.7.7.6] [SP:RPOC_ECOLI]
b4005 purD; phosphoribosylamine--glycine ligase (GARS) (glycinamide
ribonucleotide synthetase) (phosphoribosylglycinamide synthetase).
[EC:6.3.4.13] [SP:PUR2_ECOLI]
*b4006 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR
transformylase) / IMP cyclohydrolase (inosinicase) (IMP synthetase)
(ATIC). [EC:2.1.2.3 3.5.4.10] [SP:PUR9_ECOLI]
*b4177 purA, adek; adenylosuccinate synthetase (IMP--aspartate ligase).
[EC:6.3.4.4] [SP:PURA_ECOLI]
*b4213 cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor.
[EC:3.1.4.16] [SP:CN16_ECOLI]
*b4238 nrdD; anaerobic ribonucleoside-triphosphate reductase. [EC:1.17.4.2]
[SP:NRDD_ECOLI]
*b4259 holC; DNA polymerase III, chi subunit. [EC:2.7.7.7] [SP:HOLC_ECOLI]
*b4372 holD; DNA polymerase III, psi subunit. [EC:2.7.7.7] [SP:HOLD_ECOLI]
*b4382 deoA, tpp, ttg; thymidine phosphorylase (TDRPase). [EC:2.4.2.4]
[SP:TYPH_ECOLI]
*b4383 deoB, drm, thyr; phosphopentomutase (phosphodeoxyribomutase).
[EC:5.4.2.7] [SP:DEOB_ECOLI]
*b4384 deoD, pup; purine nucleoside phosphorylase (inosine phosphorylase)
(PNP). [EC:2.4.2.1] [SP:DEOD_ECOLI]