ENTRY       EC 5.3.99.4
NAME        Prostaglandin-I synthase
            Prostacyclin synthase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Other intramolecular oxidoreductases
SYSNAME     (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate 6-isomerase
REACTION    (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate =
            (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-
            $5,13-dienoate
SUBSTRATE   (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate
PRODUCT     (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-
            $5,13-dienoate
COFACTOR    Heme
COMMENT     Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).
            A heme-thiol protein.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       HSA: PTGIS(PGIS)
DBLINKS     University of Geneva ENZYME DATA BANK: 5.3.99.4
            WIT (What Is There) Metabolic Reconstruction: 5.3.99.4
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