ENTRY       EC 2.3.1.16
NAME        Acetyl-CoA C-acyltransferase
            beta-Ketothiolase
            3-Ketoacyl-CoA thiolase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:acetyl-CoA C-acyltransferase
REACTION    Acyl-CoA + Acetyl-CoA = CoA + 3-Oxoacyl-CoA
SUBSTRATE   Acyl-CoA
            Acetyl-CoA
PRODUCT     CoA
            3-Oxoacyl-CoA
PATHWAY     PATH: MAP00062  Fatty acid biosynthesis (path 2)
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00360  Phenylalanine metabolism
DISEASE     MIM: 261510  Acetyl-Coenzyme A acyltransferase (peroxisomal
                         3-oxoacyl-Coenzyme A; Pseudo-Zellweger syndrome (1)
MOTIF       PS: PS00098  [LIVM]-[NST]-x(2)-C-[SAGLI]-[ST]-[SAG]-[LIVMFYNS]-x-
                         [STAG]-[LIVM]-x(6)-[LIVM]
            PS: PS00099  [AG]-[LIVMA]-[STAGLIVM]-[STAG]-[LIVMA]-C-x-[AG]-x-[AG]-
                         x-[AG]-x-[SAG]
            PS: PS00737  N-x(2)-G-G-x-[LIVM]-[SA]-x-G-H-P-x-G-x-[ST]-G
GENES       ECO: b3845(fadA)
            BSU: yusK
            SCE: YIL160C(FOX3)
            HSA: ACAA(Hs.76260)
STRUCTURES  PDB: 1PXT  1AFW  1AFY  
DBLINKS     University of Geneva ENZYME DATA BANK: 2.3.1.16
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.16
            SCOP (Structural Classificaion of Proteins): 2.3.1.16
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