ENTRY       EC 1.1.1.225
NAME        Chlordecone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Chlordecone-alcohol:NADP+ 2-oxidoreductase
REACTION    Chlordecone alcohol + NADP+ = Chlordecone + NADPH
SUBSTRATE   Chlordecone alcohol
            NADP+
PRODUCT     Chlordecone
            NADPH
COMMENT     Chlordecone, an organochlorine pesticide, is 1,1a,3,3a,4,5,5,5a,-
            5b,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-
            -2-one.
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
GENES       HSA: CHDR(Hs.76790)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.225
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.225
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