ENTRY       EC 1.1.1.146
NAME        11beta-Hydroxysteroid dehydrogenase
            Corticosteroid 11beta-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     11beta-Hydroxysteroid:NADP+ 11-oxidoreductase
REACTION    11beta-Hydroxysteroid + NADP+ = 11-Oxosteroid + NADPH
SUBSTRATE   11beta-Hydroxysteroid
            NADP+
PRODUCT     11-Oxosteroid
            NADPH
COMMENT     The mammalian enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
            PATH: MAP00150  Androgen and estrogen metabolism
DISEASE     MIM: 218030  Hydroxysteroid (11-beta) dehydrogenase 2; Apparent
                         mineralocorticoid excess, hypertension due to (3)
MOTIF       PS: PS00061  [LIVSPADK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFR]-[LIVMTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFWGAPTH]-[GSACQRHM]
GENES       HSA: HSD11B1(HSD11)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.146
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.146
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